Taboola offers targeting based on a variety of audience types:

1. Broad Targeting - also known as run of network, where the predictive algorithm works to find the right audience
2. Advertiser 1st Party - also for retargeting purposes
   Taboola Pixel audiences
   File based audiences - available in the US, Canda, UK, France, Germany, Spain, Italy, Israel, Greece, Switzerland, Uruguay, Portugal, Turkey, India, Japan, Singapore, Australia, New Zealand, Brazil, Mexico, Argentina, Colombia, South Africa, Puerto Rico, Panama, Azerbaijan 
   Lookalikes - based off a CRM file and available only in the US
3. Audience data marketplace - including both Taboola 1st party data and 3rd party segments
4. Contextual Targeting

You can combine different audiences together, however it's important to note that too many audience overlays can result in limited reach.

It's important to always check the reach estimator to understand what you're scaling ability is like when overlaying audience targeting to your campaigns.